Description

(E)-Methyl 5-(4-Methylphenylsulfonamido)Pent-2-Enoate is a high-purity, advanced pharmaceutical intermediate characterized by its specific sulfonamide and enoate ester functional groups. This compound matters for its critical role as a key building block in the synthesis of complex, biologically active molecules, enabling precise chemical transformations. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of new therapeutic agents, particularly in medicinal chemistry and process R&D. The CAS number for this product is 868272-75-7.

Application

This specialized intermediate serves as a versatile synthon in sophisticated organic synthesis. Its primary applications include:

• Pharmaceutical Intermediate: A crucial building block for the research and development of novel active pharmaceutical ingredients (APIs), particularly those targeting specific enzyme pathways.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for drug discovery programs.
• Process Chemistry Development: Serves as a key starting material or intermediate in scaling up synthetic routes from laboratory to pilot plant scale.
• Custom Synthesis: Employed by fine chemical manufacturers for the contract synthesis of complex, high-value molecules for clients in the life sciences sector.
• Bioconjugate Chemistry: Potential use in the development of antibody-drug conjugates (ADCs) or other targeted drug delivery systems due to its reactive handles.

Basic Information

Product Name	(E)-Methyl 5-(4-Methylphenylsulfonamido)Pent-2-Enoate
CAS No.	868272-75-7
Molecular Formula	C14H19NO4S
Molecular Weight	297.37 g/mol
Synonyms	Methyl (2E)-5-[[(4-methylphenyl)sulfonyl]amino]-2-pentenoate; Methyl (E)-5-[(p-tolylsulfonyl)amino]pent-2-enoate; 868272-75-7; (E)-Methyl 5-(p-Toluenesulfonamido)pent-2-enoate; Pent-2-enoic acid, 5-[[(4-methylphenyl)sulfonyl]amino]-, methyl ester, (2E)-; Methyl 5-(4-methylbenzenesulfonamido)pent-2-enoate
EINECS	Contact for details

Quality Control

Our (E)-Methyl 5-(4-Methylphenylsulfonamido)Pent-2-Enoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to quality supports compliance with cGMP standards where required for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and away from direct light sources to maintain stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.