Description

3-Amino-5-Trifluoromethyl-Pyridine-2-Carboxylic Acid Methyl Ester is a high-value pyridine derivative and a key fluorinated building block in advanced organic synthesis. Its molecular structure, featuring both an amino group and a trifluoromethyl substituent, makes it an essential intermediate for creating complex molecules with tailored properties. This compound is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors, antiviral agents, and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Material Science Precursor: Serves as a monomer or functionalizing agent in the development of specialty polymers, liquid crystals, and organic electronic materials.
• Chemical Research & Development: Employed as a versatile scaffold in medicinal chemistry for structure-activity relationship (SAR) studies and library synthesis.
• Fluorine Chemistry: Acts as a valuable source of a fluorinated pyridine moiety for introducing the trifluoromethyl group into more complex molecular architectures.

Basic Information

Product Name	3-Amino-5-Trifluoromethyl-Pyridine-2-Carboxylic Acid Methyl Ester
CAS No.	866775-17-9
Molecular Formula	C8H7F3N2O2
Molecular Weight	220.15 g/mol
Synonyms	Methyl 3-Amino-5-(trifluoromethyl)picolinate; 2-Pyridinecarboxylic acid, 3-amino-5-(trifluoromethyl)-, methyl ester; 3-Amino-5-trifluoromethylpicolinic acid methyl ester; Methyl 3-amino-5-trifluoromethylpicolinate; 3-Amino-5-(trifluoromethyl)-2-pyridinecarboxylic acid methyl ester; 866775-17-9; Methyl 3-amino-5-(trifluoromethyl)pyridine-2-carboxylate
EINECS	Contact for details

Quality Control

Every batch of 3-Amino-5-Trifluoromethyl-Pyridine-2-Carboxylic Acid Methyl Ester is manufactured and tested under a strict quality management system. We ensure compliance with relevant industry standards for fine chemical intermediates. A comprehensive Certificate of Analysis (COA), detailing purity, identity, and impurity profiles as determined by HPLC, NMR, and MS, is provided with each shipment to guarantee traceability and batch-to-batch consistency for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.