Description

3-Amino-6-Bromopyridine-2-Carboxylic Acid Methyl Ester is a high-purity, multi-functional heterocyclic building block of significant importance in advanced organic synthesis. Its molecular structure, featuring both amino and bromo substituents on the pyridine core, makes it a versatile precursor for constructing complex pharmacophores and functional materials. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries seeking to develop novel active compounds and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, particularly in the development of kinase inhibitors, antiviral agents, and central nervous system (CNS) active compounds.
• Agrochemical Research: Used in creating advanced active ingredients for crop protection products, including herbicides and fungicides, leveraging its halogenated pyridine scaffold.
• Material Science Precursor: Serves as a building block for synthesizing functionalized ligands, organic semiconductors, and metal-organic frameworks (MOFs).
• Chemical Biology Probe Development: Utilized in medicinal chemistry to create molecular probes and labeled compounds for target identification and binding studies.
• Cross-Coupling Reactions: The bromo substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to introduce complex aryl/alkynyl groups.
• Functional Group Transformation: The ester and amino groups provide handles for further derivatization, such as hydrolysis, amidation, and diazotization, to access a wide array of analogs.

Basic Information

Product Name	3-Amino-6-Bromopyridine-2-Carboxylic Acid Methyl Ester
CAS No.	866775-09-9
Molecular Formula	C7H7BrN2O2
Molecular Weight	231.05 g/mol
Synonyms	Methyl 3-Amino-6-bromopyridine-2-carboxylate; 6-Bromo-3-aminopicolinic Acid Methyl Ester; 2-Pyridinecarboxylic acid, 3-amino-6-bromo-, methyl ester; 3-Amino-6-bromo-2-pyridinecarboxylic acid methyl ester; Methyl 3-amino-6-bromopicolinate; 3-Amino-6-bromopicolinic acid methyl ester
EINECS	Contact for details

Quality Control

Our 3-Amino-6-Bromopyridine-2-Carboxylic Acid Methyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be light-sensitive and should be handled under appropriate conditions to maintain stability. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.