Description

((3,4-Difluorophenyl) Ethynyl)Trimethylsilane CAS NO 866683-38-7 is a high-value organosilicon intermediate featuring a difluorophenyl-substituted ethynyl group protected by a trimethylsilyl (TMS) moiety. This compound is critical for its role in Sonogashira and other cross-coupling reactions, enabling the efficient synthesis of complex fluorinated aromatic systems. It is primarily sought by R&D chemists and process development teams in the pharmaceutical and advanced materials sectors for constructing novel active pharmaceutical ingredients (APIs) and organic electronic materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of fluorinated drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in creating novel fluorinated pesticides and herbicides, where the fluorine atoms enhance biological activity and environmental stability.
• Material Science Research: Serves as a precursor for conjugated polymers and small molecules in organic light-emitting diodes (OLEDs) and organic photovoltaics (OPVs).
• Ligand and Catalyst Development: Employed to synthesize sophisticated ligands for transition metal catalysis.
• Academic & Industrial R&D: A versatile reagent for exploring new synthetic methodologies involving alkynes and fluorinated arenes.
• Custom Synthesis: Foundation for contract research organizations (CROs) and CDMOs to produce bespoke fluorinated compounds for client projects.

Basic Information

Product Name	((3,4-Difluorophenyl) Ethynyl)Trimethylsilane
CAS No.	866683-38-7
Molecular Formula	C11H12F2Si
Molecular Weight	210.30 g/mol
Synonyms	Trimethyl[(3,4-difluorophenyl)ethynyl]silane; 1-[(Trimethylsilyl)ethynyl]-3,4-difluorobenzene; 3,4-Difluorophenylacetylene trimethylsilyl derivative; TMS-protected 3,4-difluorophenylacetylene; ((3,4-Difluorophenyl)ethynyl)trimethylsilane; Ethynyltrimethylsilane, (3,4-difluorophenyl)-; (3,4-Difluorophenylethynyl)trimethylsilane
EINECS	Contact for details

Quality Control

Our production of ((3,4-Difluorophenyl) Ethynyl)Trimethylsilane adheres to stringent internal quality protocols to ensure batch-to-batch consistency and high purity. Each lot is characterized by GC, NMR, and HPLC analysis. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We support cGMP compliance for advanced intermediates and can tailor specifications to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Purity (HPLC)	≥ 96.5%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.