Description

1H-Pyrrolo[2,3-B]Pyridine, 5-Chloro-1-[(4-Methylphenyl)Sulfonyl]-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl) is a high-purity, advanced pharmaceutical intermediate and a key boronic ester building block. This compound is of significant commercial importance for its role in Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern medicinal chemistry for constructing complex biaryl structures. It is primarily sought after by research institutions and pharmaceutical companies engaged in the discovery and development of novel small-molecule therapeutics, particularly kinase inhibitors and other targeted agents.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs) for oncology, antiviral, and CNS drug candidates.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronic ester reagent for the efficient formation of carbon-carbon bonds between aromatic rings.
• Medicinal Chemistry Research: Used in high-throughput screening and structure-activity relationship (SAR) studies to optimize drug-like properties.
• Kinase Inhibitor Development: The pyrrolopyridine core is a privileged scaffold in designing potent and selective kinase inhibitors.
• Chemical Biology Probes: Employed in the creation of tool compounds for studying biological pathways and target validation.
• Process Chemistry & Scale-Up: Supports route scouting and optimization for the commercial-scale manufacturing of target molecules.

Basic Information

Product Name	1H-Pyrrolo[2,3-B]Pyridine, 5-Chloro-1-[(4-Methylphenyl)Sulfonyl]-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)
CAS No.	866546-11-4
Molecular Formula	C20H24BClN2O4S
Molecular Weight	434.74 g/mol
Synonyms	5-Chloro-1-tosyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine; 5-Chloro-1-[(4-methylphenyl)sulfonyl]-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine; 5-Chloro-1-(p-toluenesulfonyl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine; 866546-11-4; 1H-Pyrrolo[2,3-b]pyridine, 5-chloro-1-[(4-methylphenyl)sulfonyl]-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; Boronic ester intermediate 866546-11-4
EINECS	Contact for details

Quality Control

Our 1H-Pyrrolo[2,3-B]Pyridine boronic ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, supporting our commitment to supplying reliable, high-quality building blocks for critical research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when appropriate to prevent degradation. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.