Description

1H-Pyrrolo[2,3-B]Pyridine, 5-Chloro-1-[(1,1-Dimethylethyl)Dimethylsilyl]- is a high-purity, protected heterocyclic building block essential for advanced organic synthesis. This compound is specifically designed to provide a reactive handle for the controlled introduction of the 5-chloro-1H-pyrrolo[2,3-b]pyridine scaffold into complex molecular architectures. It is a critical intermediate for research and development chemists working in pharmaceutical discovery and fine chemical manufacturing, where precise molecular construction is paramount.

Application

This silyl-protected chloropyrrolopyridine derivative serves as a versatile precursor in sophisticated chemical synthesis. Its primary applications include:

• Pharmaceutical Intermediate: Key building block for the synthesis of kinase inhibitors and other small molecule therapeutics targeting various disease pathways.
• Agrochemical Research: Used in the development of novel active ingredients requiring the pyrrolopyridine heterocycle.
• Material Science: Potential monomer or functional unit in the creation of organic electronic materials and advanced polymers.
• Chemical Biology: Employed in the synthesis of probes and tool compounds for studying biological systems and enzyme functions.
• Process Chemistry: Serves as a standardized intermediate in the scale-up and optimization of API (Active Pharmaceutical Ingredient) manufacturing routes.
• Custom Synthesis: Foundation for contract research organizations (CROs) and CDMOs to create bespoke compounds for client projects.

Basic Information

Product Name	1H-Pyrrolo[2,3-B]Pyridine, 5-Chloro-1-[(1,1-Dimethylethyl)Dimethylsilyl]-
CAS No.	866546-08-9
Molecular Formula	C13H19ClN2Si
Molecular Weight	266.84 g/mol
Synonyms	5-Chloro-1-[(1,1-dimethylethyl)dimethylsilyl]-1H-pyrrolo[2,3-b]pyridine; 5-Chloro-1-(tert-butyldimethylsilyl)-1H-pyrrolo[2,3-b]pyridine; 5-Chloro-1-TBDMS-1H-pyrrolo[2,3-b]pyridine; 5-Chloro-1H-pyrrolo[2,3-b]pyridine, 1-TBDMS protected; tert-Butyl(5-chloro-1H-pyrrolo[2,3-b]pyridin-1-yl)dimethylsilane; TBDMS-5-Chloropyrrolopyridine; 866546-08-9; 5-Chloro-1-(tert-butyldimethylsilyl)-7-azaindole
EINECS	Contact for details

Quality Control

Our production of 1H-Pyrrolo[2,3-B]Pyridine, 5-Chloro-1-[(1,1-Dimethylethyl)Dimethylsilyl]- adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for critical synthetic applications. Each lot is characterized by advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment. We support cGMP manufacturing standards for pharmaceutical customers.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.