Description

2,5-Pyrrolidinedione, 1-[(6-Azido-1-Oxohexyl)Oxy]- is a specialized heterocyclic compound featuring a reactive azido group, making it a valuable intermediate for advanced organic synthesis. This compound matters for its role as a versatile building block in click chemistry and bioconjugation strategies, enabling the efficient and selective formation of covalent bonds under mild conditions. It is primarily needed by research institutions and pharmaceutical companies developing novel drug candidates, biopharmaceuticals, and advanced polymer materials.

Application

• Bioconjugation Reagent: Used for site-specific labeling of proteins, antibodies, and other biomolecules via copper-catalyzed azide-alkyne cycloaddition (CuAAC) or strain-promoted azide-alkyne cycloaddition (SPAAC).
• Pharmaceutical Intermediate: Serves as a key synthon in the synthesis of active pharmaceutical ingredients (APIs) and prodrugs, particularly those requiring targeted delivery systems.
• Polymer Functionalization: Enables the modification of polymer backbones to introduce specific functional groups, enhancing material properties for specialty coatings, adhesives, and hydrogels.
• Proteomics Research: Employed in chemical proteomics for activity-based protein profiling (ABPP) and the development of diagnostic probes.
• Material Science: Used in the surface functionalization of nanoparticles and nanomaterials for biomedical and catalytic applications.
• Crosslinking Agent: Acts as a crosslinker in the development of novel biomaterials and drug delivery scaffolds.

Basic Information

Product Name	2,5-Pyrrolidinedione, 1-[(6-Azido-1-Oxohexyl)Oxy]-
CAS No.	866363-70-4
Molecular Formula	C10H14N4O4
Molecular Weight	254.24 g/mol
Synonyms	1-[(6-Azido-1-oxohexyl)oxy]-2,5-pyrrolidinedione; 6-Azidohexanoic Acid Succinimidyl Ester; NHS Ester of 6-Azidohexanoic Acid; Azidohexanoic Acid NHS Ester; 6-Azidocaproic Acid N-Hydroxysuccinimide Ester; N-Succinimidyl 6-Azidohexanoate; Azido-PEG5-NHS Ester (common trade name); 6-AHA NHS Ester
EINECS	Contact for details

Quality Control

Our 2,5-Pyrrolidinedione, 1-[(6-Azido-1-Oxohexyl)Oxy]- is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development applications. All products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label. This compound is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to moisture, heat, or light should be avoided to maintain stability and reactivity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.