Description

2-Amino-5-Chloro-3-(Trimethylsilyl)Acetylenylpyridine is a specialized organosilicon building block that integrates a pyridine core with a protected acetylene functionality. This compound matters for its role as a key intermediate in the synthesis of complex heterocyclic molecules, particularly in pharmaceutical and agrochemical research. It is needed by R&D chemists and process development scientists working on novel active ingredients, especially in the areas of drug discovery and crop protection.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and infectious diseases.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, leveraging its heterocyclic structure for biological activity.
• Material Science Research: Serves as a precursor for creating functionalized polymers and advanced organic electronic materials.
• Cross-Coupling Reactions: The trimethylsilyl-protected acetylene group is valuable in Sonogashira and other palladium-catalyzed cross-coupling reactions to construct complex molecular architectures.
• Ligand Development: Utilized in the preparation of novel nitrogen-containing ligands for catalysis.
• Chemical Biology Probes: Acts as a scaffold for developing molecular probes and diagnostic agents.

Basic Information

Item	Details
Product Name	2-Amino-5-Chloro-3-(Trimethylsilyl)Acetylenylpyridine
CAS No.	866318-90-3
Molecular Formula	C10H13ClN2Si
Molecular Weight	224.76 g/mol
Synonyms	5-Chloro-3-[(trimethylsilyl)ethynyl]pyridin-2-amine; 2-Amino-5-chloro-3-ethynylpyridine, trimethylsilyl derivative; 3-((Trimethylsilyl)ethynyl)-5-chloropyridin-2-amine; 5-Chloro-3-(trimethylsilylethynyl)pyridin-2-amine; 2-Pyridinamine, 5-chloro-3-[(trimethylsilyl)ethynyl]-; TMS-protected 2-amino-5-chloro-3-ethynylpyridine
EINECS	Contact for details

Quality Control

Our 2-Amino-5-Chloro-3-(Trimethylsilyl)Acetylenylpyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and batch-to-batch consistency suitable for research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C under an inert atmosphere (e.g., nitrogen or argon) due to its sensitivity to oxidation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.