Description

Methyl 5-Hydroxy-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-3-carboxylate is a high-purity heterocyclic building block and pharmaceutical intermediate of significant commercial interest. Its fused pyrazolopyridine structure makes it a valuable scaffold for medicinal chemistry research and the synthesis of novel active pharmaceutical ingredients (APIs). This compound is primarily sought by R&D and process development teams in the pharmaceutical, agrochemical, and fine chemical industries for constructing complex molecules with potential biological activity.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates targeting central nervous system (CNS) disorders, inflammation, and other therapeutic areas.
• Medicinal Chemistry Research: Used as a core scaffold in hit-to-lead optimization and structure-activity relationship (SAR) studies due to its privileged heterocyclic structure.
• Agrochemical Synthesis: Intermediate in the development of new generation pesticides and herbicides, leveraging its bioactive pyrazolopyridine core.
• Fine Chemical Production: Serves as a precursor for specialized dyes, pigments, and functional materials requiring complex nitrogen-containing heterocycles.
• Contract Research & Manufacturing (CRAM): Supplied to organizations offering custom synthesis and process development services for client projects.
• Academic Research: Utilized in university and institutional labs for methodological development in organic synthesis and heterocyclic chemistry.

Basic Information

Product Name	Methyl 5-Hydroxy-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-3-carboxylate
CAS No.	866216-23-1
Molecular Formula	C10H12N2O3
Molecular Weight	208.22 g/mol
Synonyms	5-Hydroxy-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-3-carboxylic acid methyl ester; Methyl 5-hydroxypyrazolo[1,5-a]pyridine-3-carboxylate (tetrahydro); 4,5,6,7-Tetrahydro-5-hydroxy-pyrazolo[1,5-a]pyridine-3-carboxylic acid methyl ester; 5-Hydroxy-4,5,6,7-tetrahydro-1H-pyrazolo[1,5-a]pyridine-3-carboxylic acid methyl ester; Pyrazolo[1,5-a]pyridine-3-carboxylic acid, 4,5,6,7-tetrahydro-5-hydroxy-, methyl ester
EINECS	Contact for details

Quality Control

Our production of Methyl 5-Hydroxy-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-3-carboxylate adheres to stringent quality management protocols. Every batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis by GC. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to protect this moisture-sensitive compound.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.