Description

5-Fluoro-1,2-Dihydro-2-Oxo-Spiro[3H-Indole-3,4'-Piperidine]-1'-Carboxylic Acid 1,1-Dimethylethyl Ester is a high-purity, advanced pharmaceutical intermediate of significant importance in modern medicinal chemistry. Its complex spirocyclic indole-piperidine scaffold makes it a valuable building block for the research and development of novel therapeutic agents. This compound is primarily sought after by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in synthesizing complex bioactive molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly those targeting central nervous system (CNS) disorders.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Spirocyclic Compound Synthesis: Serves as a critical starting material for constructing other spiro-fused heterocyclic systems with potential biological activity.
• API Development: Employed in the development and scale-up processes for Active Pharmaceutical Ingredients (APIs) requiring this specific fluorinated indole-piperidine core.
• Contract Research & Manufacturing (CRAM): Supplied to organizations specializing in custom synthesis and process development for the pharmaceutical industry.
• Biochemical Tool Compound: Potential use in developing probes for studying biological pathways and enzyme interactions.

Basic Information

Product Name	5-Fluoro-1,2-Dihydro-2-Oxo-Spiro[3H-Indole-3,4'-Piperidine]-1'-Carboxylic Acid 1,1-Dimethylethyl Ester
CAS No.	866028-06-0
Molecular Formula	C18H21FN2O3
Molecular Weight	332.37 g/mol
Synonyms	5-Fluoro-2-oxospiro[indole-3,4'-piperidine]-1'-carboxylic acid tert-butyl ester; tert-Butyl 5-fluoro-2-oxo-1,2-dihydrospiro[indole-3,4'-piperidine]-1'-carboxylate; 5-Fluoro-1,2-dihydro-2-oxospiro[3H-indole-3,4'-piperidine]-1'-carboxylic acid tert-butyl ester; 5-Fluoro-2-oxospiro[indoline-3,4'-piperidine]-1'-carboxylic acid tert-butyl ester; Spiro[indole-3,4'-piperidine] intermediate; BOC-protected 5-fluoro spiroindolone piperidine; CAS 866028-06-0
EINECS	Contact for details

Quality Control

Our 5-Fluoro-1,2-Dihydro-2-Oxo-Spiro[3H-Indole-3,4'-Piperidine]-1'-Carboxylic Acid 1,1-Dimethylethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical intermediates. Certificates of Analysis (COA) detailing batch-specific results are provided and can be tailored to meet client specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed when not in use to prevent exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.