Description

3-Bromo-5-(Tosylmethyl)Pyridine is a high-value, multi-functional pyridine derivative and an important synthetic intermediate in advanced organic chemistry. Its core value lies in its dual reactive sites—the bromine and the tosylmethyl group—which enable precise, sequential functionalization for constructing complex molecular architectures. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries who require reliable, high-purity building blocks for drug discovery and specialty chemical synthesis.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the development of novel pesticides and herbicides, leveraging its halogenated pyridine core.
• Ligand and Catalyst Development: Serves as a versatile scaffold for constructing sophisticated ligands used in transition metal catalysis and asymmetric synthesis.
• Material Science Precursor: Employed in the research and development of organic electronic materials, such as charge-transport layers and light-emitting compounds.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions.
• Nucleophilic Substitution: The tosylmethyl group acts as a good leaving group, facilitating nucleophilic attacks to introduce new carbon chains or functional groups.

Basic Information

Product Name	3-Bromo-5-(Tosylmethyl)Pyridine
CAS No.	866021-35-4
Molecular Formula	C13H12BrNO2S
Molecular Weight	326.21 g/mol
Synonyms	3-Bromo-5-[(4-methylphenyl)sulfonyl]methylpyridine; 5-(Bromomethyl)-3-pyridyl p-tolyl sulfone; Pyridine, 3-bromo-5-[(4-methylphenyl)sulfonyl]methyl-; 3-Bromo-5-(p-tolylsulfonylmethyl)pyridine; 3-Bromo-5-(tosylmethyl)pyridine; 3-Bromo-5-(4-methylbenzenesulfonylmethyl)pyridine
EINECS	Contact for details

Quality Control

Our 3-Bromo-5-(Tosylmethyl)Pyridine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes. We support cGMP-compliant production for pharmaceutical applications and can tailor specifications to meet your specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.