Description

4-(2-Trimethylsilylethynyl)Pyridin-2-Amine is a high-purity, functionalized pyridine derivative featuring a trimethylsilyl-protected alkyne group, making it a versatile and valuable building block in advanced organic synthesis. This compound is specifically engineered for applications requiring precise molecular architecture and robust chemical functionality. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for constructing complex molecules, including active pharmaceutical ingredients (APIs) and specialty polymers.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel drug candidates, particularly in constructing heterocyclic cores for kinase inhibitors and other targeted therapies.
• Agrochemical Research: Used in developing advanced crop protection agents and herbicides due to its reactive alkyne functionality.
• Material Science & OLED Development: Serves as a precursor for organic semiconductors, light-emitting materials, and other functional materials where the pyridine and alkyne moieties are critical.
• Cross-Coupling Reactions: An excellent substrate for Sonogashira, Heck, and other palladium-catalyzed cross-coupling reactions to create complex conjugated systems.
• Ligand Synthesis: Employed in the preparation of novel nitrogen-containing ligands for catalysis and coordination chemistry.
• Chemical Biology & Bioconjugation: The protected alkyne allows for efficient "click chemistry" (CuAAC) reactions for labeling and modifying biomolecules.

Basic Information

Product Name	4-(2-Trimethylsilylethynyl)Pyridin-2-Amine
CAS No.	865798-13-6
Molecular Formula	C11H16N2Si
Molecular Weight	204.35 g/mol
Synonyms	2-Amino-4-[(trimethylsilyl)ethynyl]pyridine; 4-(Trimethylsilylethynyl)pyridin-2-amine; 4-(2-Trimethylsilylethynyl)-2-aminopyridine; 4-[(Trimethylsilyl)ethynyl]pyridin-2-amine; 2-Pyridinamine, 4-[(trimethylsilyl)ethynyl]-; 865798-13-6; 4-(TMS-ethynyl)pyridin-2-amine
EINECS	Contact for details

Quality Control

Every batch of 4-(2-Trimethylsilylethynyl)Pyridin-2-Amine is manufactured and tested under strict quality management systems to ensure consistency and reliability for your critical research and development processes. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.