Description

4-Pyridinecarbonitrile, 3-[[[(1,1-Dimethylethyl)dimethylsilyl]oxy]methyl]- is a high-value, protected pyridine derivative that serves as a critical synthetic intermediate. Its core value proposition lies in enabling complex organic synthesis, particularly in pharmaceutical research and development, by providing a reactive nitrile group and a protected hydroxymethyl functionality. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing novel molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially in kinase inhibitor and other small-molecule drug discovery programs.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides, leveraging its pyridine core structure.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of functionalized organic molecules for electronic or photonic materials.
• Chemical Biology Probes: Useful in the design and synthesis of molecular probes for studying biological systems and enzyme mechanisms.
• Custom Synthesis and Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences industry.

Basic Information

Product Name	4-Pyridinecarbonitrile, 3-[[[(1,1-Dimethylethyl)dimethylsilyl]oxy]methyl]-
CAS No.	865610-86-2
Molecular Formula	C13H20N2OSi
Molecular Weight	248.40 g/mol
Synonyms	3-((tert-Butyldimethylsilyloxy)methyl)isonicotinonitrile; 3-(((tert-Butyldimethylsilyl)oxy)methyl)pyridine-4-carbonitrile; 3-((TBDMS-Oxy)Methyl)isonicotinonitrile; 4-Cyano-3-((tert-butyldimethylsilyloxy)methyl)pyridine; 3-[(tert-Butyldimethylsilyloxy)methyl]pyridine-4-carbonitrile; 3-[[(tert-Butyldimethylsilyl)oxy]methyl]isonicotinonitrile; TBDMS-protected 3-hydroxymethyl-4-cyanopyridine
EINECS	Contact for details

Quality Control

Our 4-Pyridinecarbonitrile, 3-[[[(1,1-Dimethylethyl)dimethylsilyl]oxy]methyl]- is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and batch-to-batch consistency essential for sensitive R&D and scale-up processes. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.