Description

tert-Butyl 3-Ethoxycarbonylmethylene-8-Aza-Bicyclo[3.2.1]Octane-8-Carboxylate is a sophisticated bicyclic organic compound that serves as a critical advanced intermediate in modern pharmaceutical synthesis. Its unique bridged nitrogen-containing structure makes it a valuable building block for constructing complex molecules with specific three-dimensional architectures. This high-purity intermediate is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), particularly within the central nervous system (CNS) and therapeutic areas requiring constrained molecular frameworks.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of complex drug candidates, especially those with tropane or related alkaloid-like structures.
• Medicinal Chemistry Research: Used as a versatile scaffold for constructing molecular libraries in drug discovery programs targeting neurological receptors.
• Process Chemistry Development: Employed in route scouting and optimization for the scalable production of target molecules in Good Manufacturing Practice (GMP) environments.
• Asymmetric Synthesis: Utilized in chiral synthesis due to its rigid, three-dimensional framework which can impart stereochemical control in subsequent reactions.
• Chemical Biology Probes: Serves as a core structure for developing tool compounds and probes used to study biological pathways and protein function.

Basic Information

Product Name	tert-Butyl 3-Ethoxycarbonylmethylene-8-Aza-Bicyclo[3.2.1]Octane-8-Carboxylate
CAS No.	865106-60-1
Molecular Formula	C16H25NO4
Molecular Weight	295.37 g/mol
Synonyms	8-tert-Butoxycarbonyl-3-ethoxycarbonylmethylene-8-azabicyclo[3.2.1]octane; 3-(Ethoxycarbonylmethylene)-8-azabicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester; 8-Azabicyclo[3.2.1]octane-8-carboxylic acid, 3-[(ethoxycarbonyl)methylene]-, 1,1-dimethylethyl ester; tert-Butyl 3-(ethoxycarbonylmethylidene)-8-azabicyclo[3.2.1]octane-8-carboxylate; BOC-8-Aza-3-methylene-ethoxycarbonyl-bicyclo[3.2.1]octane
EINECS	Contact for details

Quality Control

Our tert-Butyl 3-Ethoxycarbonylmethylene-8-Aza-Bicyclo[3.2.1]Octane-8-Carboxylate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and pharmaceutical applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to relevant industry standards and can provide material tailored to specific project requirements, including custom purity grades.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be sensitive to prolonged exposure to moisture and elevated temperatures.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.