Description

3-Azido-2-Fluoropyridine (CAS NO 864866-10-4) is a high-value, multi-functional heterocyclic building block designed for advanced synthetic chemistry. Its unique combination of an azido group and fluorine substitution makes it a critical reagent for click chemistry, bioorthogonal labeling, and the synthesis of complex pharmaceutical intermediates. This compound is essential for researchers and process chemists in pharmaceutical R&D, agrochemical discovery, and materials science who require reliable, high-purity intermediates to accelerate innovation.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for fluorine-containing drug candidates.
• Click Chemistry Reagent: Utilized in copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions for bioconjugation, polymer modification, and materials surface functionalization.
• Agrochemical Synthesis: Serves as a building block for developing new herbicides, fungicides, and insecticides with enhanced efficacy and selectivity.
• Ligand and Catalyst Development: Used to create novel pyridine-based ligands for catalysis and metal-organic frameworks (MOFs).
• Fluorine Chemistry Research: A valuable substrate for studying fluorination reactions and the effects of fluorine atoms on molecular properties.
• Diagnostic Probe Synthesis: Employed in the development of fluorescent probes and imaging agents for biological research.

Basic Information

Item	Details
Product Name	3-Azido-2-Fluoropyridine
CAS No.	864866-10-4
Molecular Formula	C5H3FN4
Molecular Weight	138.10 g/mol
Synonyms	2-Fluoro-3-azidopyridine; 3-Azido-2-fluoropyridine; 2-Fluoropyridin-3-yl azide; Azidopyridine derivative; Fluorinated azidopyridine; Pyridine, 3-azido-2-fluoro-; Building block 864866-10-4; Heterocyclic azide
EINECS	Contact for details

Quality Control

Our 3-Azido-2-Fluoropyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its properties of being easily oxidized (store under inert atmosphere) and highly volatile, it is recommended to handle under an inert atmosphere (e.g., nitrogen or argon) and minimize exposure to air and moisture. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95% (Standard Grade)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.