Description

(3R,4S)-1-Boc-4-Amino-Piperidine-3-Carboxylic Acid Ethyl Ester is a high-purity, stereochemically defined chiral piperidine derivative that serves as a critical building block in modern organic synthesis. Its value lies in providing a protected, multifunctional scaffold essential for constructing complex molecules with precise three-dimensional control. This compound is primarily needed by pharmaceutical R&D and fine chemical manufacturers for applications in medicinal chemistry, particularly in the development of novel active pharmaceutical ingredients (APIs) and bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of drug candidates targeting neurological disorders, oncology, and infectious diseases.
• Peptidomimetic Chemistry: Used to incorporate constrained, non-natural amino acid motifs into peptide backbones to enhance stability and bioavailability.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Chemical Biology Probes: Employed in the construction of molecular probes for studying enzyme function and protein-protein interactions.
• Custom Synthesis & Contract Manufacturing: A fundamental starting material for custom synthesis projects requiring high stereochemical fidelity.

Basic Information

Product Name	(3R,4S)-1-Boc-4-Amino-Piperidine-3-Carboxylic Acid Ethyl Ester
CAS No.	864853-17-8
Molecular Formula	C13H24N2O4
Molecular Weight	272.34 g/mol
Synonyms	1-Boc-4-amino-3-carbethoxypiperidine; Ethyl 1-(tert-butoxycarbonyl)-4-amino-3-piperidinecarboxylate; 4-Amino-1-Boc-piperidine-3-carboxylic acid ethyl ester; 1-N-Boc-4-amino-3-piperidinecarboxylic acid ethyl ester; (3R,4S)-1-(tert-Butoxycarbonyl)-4-aminopiperidine-3-carboxylic acid ethyl ester; 864853-17-8; tert-Butyl (3R,4S)-4-amino-3-(ethoxycarbonyl)piperidine-1-carboxylate
EINECS	Contact for details

Quality Control

Our (3R,4S)-1-Boc-4-Amino-Piperidine-3-Carboxylic Acid Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high chemical and enantiomeric purity suitable for advanced synthetic applications. Certificates of Analysis (COA) with full analytical data are provided to guarantee traceability, consistency, and compliance with your project specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.