Description

Methyl 5-Cyano-6-(2,2-Difluoroethylthio)-2-(Dimethoxymethyl)Nicotinate is a high-value, multi-functional chemical intermediate characterized by its unique nicotinate core and difluoroethylthio side chain. This compound matters for its role as a critical building block in the synthesis of advanced pharmaceutical agents and agrochemicals, enabling the introduction of specific fluorine-containing motifs known to enhance biological activity and metabolic stability. It is primarily needed by research and development teams, as well as process chemists, in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in oncology, antiviral, and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, where the fluorine atoms contribute to improved efficacy and environmental profile.
• Chemical Research & Development: Serves as a versatile scaffold for medicinal chemistry and process optimization studies in contract research organizations (CROs) and academic labs.
• Fluorine Chemistry Building Block: Provides a source of the difluoroethylthio group for introducing fluorinated moieties into complex molecules to modulate their physicochemical properties.
• Fine Chemical Production: Employed in the multi-step synthesis of other high-value specialty chemicals and advanced materials.

Basic Information

Product Name	Methyl 5-Cyano-6-(2,2-Difluoroethylthio)-2-(Dimethoxymethyl)Nicotinate
CAS No.	864685-31-4
Molecular Formula	C14H16F2N2O4S
Molecular Weight	346.35 g/mol
Synonyms	Methyl 5-cyano-6-[(2,2-difluoroethyl)sulfanyl]-2-(dimethoxymethyl)pyridine-3-carboxylate; 3-Pyridinecarboxylic acid, 5-cyano-6-[(2,2-difluoroethyl)thio]-2-(dimethoxymethyl)-, methyl ester; 864685-31-4; Methyl 5-cyano-6-(2,2-difluoroethylthio)-2-(dimethoxymethyl)-3-pyridinecarboxylate; 2-(Dimethoxymethyl)-5-cyano-6-(2,2-difluoroethylthio)nicotinic acid methyl ester
EINECS	Contact for details

Quality Control

Our Methyl 5-Cyano-6-(2,2-Difluoroethylthio)-2-(Dimethoxymethyl)Nicotinate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply and traceability for critical R&D and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light). For long-term storage, consider inert gas purging to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.