Description

2-Fluoro-3,4,5-Trimethoxy-Benzoic Acid Methyl Ester is a high-purity fluorinated aromatic building block of significant interest in advanced organic synthesis. Its value lies in the strategic placement of fluorine and methoxy groups, which are crucial for modulating the electronic properties, lipophilicity, and metabolic stability of target molecules. This compound is primarily sought by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for constructing complex molecules in medicinal chemistry programs, particularly for candidates targeting CNS disorders and oncology.
• Agrochemical Research: Used in the synthesis of novel herbicides and fungicides, where the fluorine atom can enhance biological activity and environmental persistence.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for creating fluorinated aromatic cores in electronic and display materials.
• Chemical Biology Probe Development: Employed to introduce fluorine tags or modify scaffold properties in tool compounds for studying biological mechanisms.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds under cGMP or research-grade conditions.
• Academic & Institutional Research: Utilized in universities and R&D institutes for methodological studies in fluorination and cross-coupling chemistry.

Basic Information

Product Name	2-Fluoro-3,4,5-Trimethoxy-Benzoic Acid Methyl Ester
CAS No.	864684-82-2
Molecular Formula	C11H13FO5
Molecular Weight	244.22 g/mol
Synonyms	Methyl 2-Fluoro-3,4,5-trimethoxybenzoate; Benzoic acid, 2-fluoro-3,4,5-trimethoxy-, methyl ester; 3,4,5-Trimethoxy-2-fluorobenzoic acid methyl ester; 2-Fluoro-3,4,5-trimethoxybenzoic acid methyl ester; Methyl 2-fluoro-3,4,5-trimethoxybenzoate; 864684-82-2; 2-Fluoro-3,4,5-trimethoxymethyl benzoate
EINECS	Contact for details

Quality Control

Every batch of 2-Fluoro-3,4,5-Trimethoxy-Benzoic Acid Methyl Ester is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure identity, purity, and consistency, supporting both research and scale-up activities. Certificates of Analysis (COA) detailing specifications such as HPLC purity, NMR confirmation, and residual solvent levels are available for all shipments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and oxidizing agents. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.