Description

Azido-PEG4-t-butyl acetate is a heterobifunctional polyethylene glycol (PEG) derivative featuring a reactive azide group and a protected carboxylic acid. This compound is a crucial building block in bioconjugation and materials science, enabling the formation of stable triazole linkages via click chemistry. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostics industries for the synthesis of peptide-PEG conjugates, antibody-drug conjugates (ADCs), and functionalized biomaterials.

Application

• Bioconjugation Linker: Used for site-specific modification of proteins, antibodies, and peptides via copper-catalyzed azide-alkyne cycloaddition (CuAAC).
• ADC (Antibody-Drug Conjugate) Development: Serves as a hydrophilic spacer to connect cytotoxic payloads to monoclonal antibodies, improving solubility and pharmacokinetics.
• Polymer and Materials Functionalization: Incorporates azide functionality into polymers, surfaces, and nanoparticles for subsequent click chemistry modifications.
• Proteomics Research: Acts as a chemical probe for labeling and enriching biomolecules in activity-based protein profiling (ABPP).
• Crosslinking Agent: Utilized in the preparation of hydrogels and crosslinked biomaterials with tailored properties.
• Diagnostic Reagent Synthesis: Employed in the creation of labeled probes and contrast agents for imaging applications.

Basic Information

Product Name	Azido-PEG4-t-butyl acetate
CAS No.	864681-04-9
Molecular Formula	C17H33N3O7
Molecular Weight	391.46 g/mol
Synonyms	Azido-PEG4-CH2COOtBu; 2,5,8,11-Tetraoxatetradecan-14-oic acid, 13-azido-4,4-dimethyl-, 1,1-dimethylethyl ester; 1-tert-Butyl 2-(2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethoxy)acetate; Azido-PEG4-t-butyl ester; N3-PEG4-COOtBu; PEG4-Azide t-Butyl Acetate; t-Butyl 11-azido-3,6,9-trioxaundecanoate
EINECS	Contact for details

Quality Control

Our Azido-PEG4-t-butyl acetate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent performance for critical research and development applications. Certificates of Analysis (COA) with detailed specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Keep container tightly sealed in a desiccated environment.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.