Description

Simvastatin 4'-Methyl Ether is a key pharmaceutical intermediate and chemical building block. This compound is of significant value in the research and development of novel therapeutic agents, particularly within the statin class. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of advanced drug candidates and reference standards.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of Simvastatin analogs and other cholesterol-lowering agents.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the development of new HMG-CoA reductase inhibitors.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.
• Chemical Synthesis: Employed as a specialized building block in organic synthesis for introducing specific methyl ether functionalities.
• Process Development: Used in scaling up and optimizing synthetic routes for active pharmaceutical ingredients (APIs).

Basic Information

Product Name	Simvastatin 4'-Methyl Ether
CAS No.	864357-88-0
Molecular Formula	C26H40O6
Molecular Weight	448.60 g/mol
Synonyms	4'-O-Methyl Simvastatin; Simvastatin 4'-Methyl Ether; (1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-Hydroxy-6-oxo-3,4,5,6-tetrahydro-2H-pyran-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2S)-2-methylbutanoate 4'-Methyl Ether; 4'-Methoxy Simvastatin; Simvastatin 4'-OMe
EINECS	Contact for details

Quality Control

Our Simvastatin 4'-Methyl Ether is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.