Description

Methyl 2-Amino-5-Fluoro-4-Morpholinobenzoate is a high-purity, advanced pharmaceutical intermediate characterized by its distinct benzoate structure incorporating fluorine and morpholine functional groups. This compound is of critical importance for its role as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly in oncology and targeted therapy research. It is primarily needed by pharmaceutical R&D laboratories, process development chemists, and manufacturers engaged in the production of novel small-molecule drugs.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of novel drug candidates, especially in oncology and kinase inhibitor development.
• Research & Development: Used in academic and industrial research settings for exploring new chemical entities and structure-activity relationships (SAR).
• Process Chemistry: Serves as a defined starting material or intermediate in scale-up and optimization studies for API manufacturing processes.
• Chemical Synthesis: Utilized in organic synthesis to introduce the 2-amino-5-fluoro-4-morpholinobenzoate moiety into more complex molecular architectures.
• Reference Standard: Can be supplied as a high-purity standard for analytical method development, validation, and quality control in pharmaceutical production.

Basic Information

Product Name	Methyl 2-Amino-5-Fluoro-4-Morpholinobenzoate
CAS No.	864292-15-9
Molecular Formula	C12H15FN2O3
Molecular Weight	254.26 g/mol
Synonyms	Methyl 2-amino-5-fluoro-4-(morpholin-4-yl)benzoate; 2-Amino-5-fluoro-4-morpholinobenzoic acid methyl ester; 4-Morpholinebenzoic acid, 2-amino-5-fluoro-, methyl ester; Benzoic acid, 2-amino-5-fluoro-4-morpholino-, methyl ester; Methyl 2-amino-5-fluoro-4-(4-morpholinyl)benzoate; 864292-15-9; Methyl 2-Amino-4-morpholino-5-fluorobenzoate
EINECS	Contact for details

Quality Control

Our Methyl 2-Amino-5-Fluoro-4-Morpholinobenzoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for pharmaceutical R&D and production. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (typically 15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Purity (HPLC)	≥98.0%
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤2.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.