Description

5-(n-Boc-Aminomethyl)-2-Bromopyridine is a high-purity, protected amine intermediate of significant importance in modern synthetic chemistry. This compound is specifically designed for the controlled introduction of an aminomethylpyridine moiety into complex molecular architectures, offering a strategic handle for further functionalization. It is an essential building block for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly in the development of active pharmaceutical ingredients (APIs) and novel bioactive compounds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of drug candidates, especially those targeting kinase inhibition or requiring pyridine-based pharmacophores.
• Peptide Mimetics & PROTACs: Used to incorporate rigid, heterocyclic spacers and linking groups in the design of peptide mimetics and Proteolysis Targeting Chimeras (PROTACs).
• Ligand Synthesis for Catalysis: Serves as a starting material for creating sophisticated nitrogen-containing ligands used in transition metal catalysis.
• Agrochemical Research: Employed in the development of new herbicides and pesticides where the bromopyridine structure is a core component.
• Material Science: Can be utilized to synthesize functionalized monomers or additives for advanced polymers and materials.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl systems.

Basic Information

Product Name	5-(n-Boc-Aminomethyl)-2-Bromopyridine
CAS No.	864266-29-5
Molecular Formula	C12H17BrN2O2
Molecular Weight	301.18 g/mol
Synonyms	2-Bromo-5-((tert-butoxycarbonylamino)methyl)pyridine; 5-((tert-Butoxycarbonylamino)methyl)-2-bromopyridine; 2-Bromo-5-(((Boc)amino)methyl)pyridine; tert-Butyl N-[(6-bromopyridin-3-yl)methyl]carbamate; N-Boc-5-Aminomethyl-2-bromopyridine; Boc-AMBP; 5-(Boc-aminomethyl)-2-bromopyridine; 864266-29-5
EINECS	Contact for details

Quality Control

Our 5-(n-Boc-Aminomethyl)-2-Bromopyridine is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and scale-up applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity and impurity profiles. Our quality system is designed to meet the stringent requirements of cGMP and ISO standards for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container sealed to protect this light-sensitive compound from degradation and to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC)	≥ 98.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.