Description

2-(Chloromethyl)-3-(Trifluoromethyl)Pyridine Hydrochloride is a high-value, multi-functional chemical intermediate characterized by its reactive chloromethyl and electron-withdrawing trifluoromethyl groups. This compound matters for its critical role in constructing complex molecular architectures, particularly in the synthesis of advanced active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce pyridine-based scaffolds with halogen and fluorine functionalities.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, especially in kinase inhibitor and central nervous system (CNS) active compound research.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the pyridine core and fluorine atoms enhance biological activity and environmental stability.
• Ligand and Catalyst Preparation: Serves as a precursor for creating specialized ligands used in catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the development of organic electronic materials and functional polymers.
• Custom Synthesis and Contract Manufacturing: A vital starting material for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	2-(Chloromethyl)-3-(Trifluoromethyl)Pyridine Hydrochloride
CAS No.	864264-98-2
Molecular Formula	C7H6ClF3N•HCl
Molecular Weight	232.49 g/mol (Free base: 195.58 g/mol)
Synonyms	3-(Trifluoromethyl)-2-(chloromethyl)pyridine hydrochloride; 2-(Chloromethyl)-3-(trifluoromethyl)pyridine HCl; 2-Chloromethyl-3-trifluoromethylpyridine hydrochloride; Pyridine, 2-(chloromethyl)-3-(trifluoromethyl)-, hydrochloride (1:1); 864264-98-2 (CAS)
EINECS	Contact for details

Quality Control

Every batch of 2-(Chloromethyl)-3-(Trifluoromethyl)Pyridine Hydrochloride is produced and tested under strict quality management systems. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under dry conditions to prevent degradation. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.