Description

2-[(3R)-3-Methylpiperazin-1-Yl]Nicotinonitrile is a high-purity chiral intermediate featuring a nicotinonitrile core linked to a stereochemically defined methylpiperazine moiety. This compound is of significant value in pharmaceutical research and development, particularly for its role as a key building block in the synthesis of active pharmaceutical ingredients (APIs). It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries for creating novel therapeutic agents, especially in areas like kinase inhibitors and central nervous system (CNS) drugs.

Application

• Pharmaceutical Intermediate: A critical chiral building block for the synthesis of novel Active Pharmaceutical Ingredients (APIs).
• Kinase Inhibitor Development: Used in research and production of targeted cancer therapies and other disease-modifying drugs.
• Chemical Synthesis: Serves as a versatile precursor in organic synthesis for introducing the (3R)-3-methylpiperazine pharmacophore.
• Process Chemistry & Scale-up: Employed in process optimization and pilot-scale manufacturing of advanced drug candidates.
• Biochemical Research: Utilized as a reference standard or ligand in biochemical assays and structure-activity relationship (SAR) studies.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP production.

Basic Information

Product Name	2-[(3R)-3-Methylpiperazin-1-Yl]Nicotinonitrile
CAS No.	863713-32-0
Molecular Formula	C11H14N4
Molecular Weight	202.26 g/mol
Synonyms	2-((3R)-3-Methyl-1-piperazinyl)-3-pyridinecarbonitrile; (R)-2-(3-Methylpiperazin-1-yl)nicotinonitrile; 3-Pyridinecarbonitrile, 2-[(3R)-3-methyl-1-piperazinyl]-; 2-[(3R)-3-Methylpiperazin-1-yl]nicotinonitrile; 863713-32-0; Nicotinonitrile, 2-[(3R)-3-methyl-1-piperazinyl]-; (R)-2-(3-Methylpiperazin-1-yl)nicotinonitrile
EINECS	Contact for details

Quality Control

Our 2-[(3R)-3-Methylpiperazin-1-Yl]Nicotinonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and cGMP applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral excess, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.