Description

4-Methyl-3-oxo-2,3-dihydro-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid (Saltdata: Free) is a high-purity, advanced pharmaceutical intermediate belonging to the pyrazolopyridine class of heterocyclic compounds. This compound is of significant commercial interest for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring complex molecular architectures. It is primarily sought by research institutions, custom synthesis houses, and pharmaceutical manufacturers engaged in the development of new chemical entities. The product, identified by CAS number 862273-50-5, is supplied under stringent quality controls to ensure batch-to-batch consistency for demanding R&D and scale-up processes.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of complex drug candidates, particularly in oncology and central nervous system (CNS) therapeutic research.
• Active Pharmaceutical Ingredient (API) Development: Used as a core scaffold for constructing novel APIs with potential kinase inhibitory or other targeted biological activities.
• Contract Research & Manufacturing (CRAM): Supplied to organizations specializing in custom chemical synthesis for pharmaceutical clients.
• Chemical Reference Standard: Provides a high-purity standard for analytical method development, validation, and quality control in regulatory submissions.
• Academic & Industrial R&D: Utilized in medicinal chemistry programs for structure-activity relationship (SAR) studies and lead optimization.
• Process Chemistry: Employed in route scouting and optimization for the efficient, scalable production of target molecules.

Basic Information

Product Name	4-Methyl-3-oxo-2,3-dihydro-1H-pyrazolo[3,4-b]pyridine-6-carboxylic acid (Saltdata: Free)
CAS No.	862273-50-5
Molecular Formula	C9H7N3O3
Molecular Weight	205.17 g/mol
Synonyms	4-Methyl-3-oxo-3,4-dihydro-2H-pyrazolo[3,4-b]pyridine-6-carboxylic acid; 1H-Pyrazolo[3,4-b]pyridine-6-carboxylic acid, 2,3-dihydro-4-methyl-3-oxo-; 862273-50-5; 4-Methyl-3-oxo-2,3-dihydro-1H-pyrazolo[3,4-b]pyridine-6-carboxylic Acid; 6-Carboxy-4-methyl-1H-pyrazolo[3,4-b]pyridin-3(2H)-one
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring it meets the exacting standards required for pharmaceutical development. Each batch is characterized and released with a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. While produced under GMP-like conditions suitable for non-clinical and early-phase clinical applications, specifications can be aligned with client-specific pharmacopeial requirements (e.g., ICH guidelines) for impurity thresholds and analytical procedures.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This compound may be moisture-sensitive; therefore, the container should be kept tightly sealed when not in use to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.