Description

Ethyl 4-[3-Amino-1-(Trifluoromethyl)Propoxy]-1-Methyl-1H-Pyrazolo[3,4-B]Pyridine-5-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a unique trifluoromethyl-substituted pyrazolopyridine scaffold. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of novel drug candidates with enhanced metabolic stability and bioavailability. Pharmaceutical R&D and fine chemical synthesis companies need this precise intermediate for developing targeted therapies, particularly in oncology and central nervous system (CNS) disease research.

Application

• Pharmaceutical Intermediate: A key synthetic precursor for the development of novel small-molecule drug candidates, particularly kinase inhibitors.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs due to its versatile pyrazolopyridine core.
• API Synthesis: Serves as a crucial building block in the multi-step synthesis of Active Pharmaceutical Ingredients (APIs) for preclinical and clinical trials.
• Oncology Drug Development: Employed in the research and synthesis of potential anti-cancer agents targeting specific protein kinases.
• CNS Drug Discovery: Utilized in creating compounds for neurological and psychiatric disorder research, leveraging the blood-brain barrier permeability often associated with its chemical class.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP guidelines.
• Biochemical Tool Compound: Acts as a reference standard or a starting material for creating biochemical probes in pharmacological assays.

Basic Information

Item	Details
Product Name	Ethyl 4-[3-Amino-1-(Trifluoromethyl)Propoxy]-1-Methyl-1H-Pyrazolo[3,4-B]Pyridine-5-Carboxylate
CAS No.	860610-42-0
Molecular Formula	C16H17F3N4O3
Molecular Weight	370.33 g/mol
Synonyms	4-[(3-Amino-1-(trifluoromethyl)propoxy]-1-methyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester; Ethyl 4-(3-amino-1-(trifluoromethyl)propoxy)-1-methyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylate; 1-Methyl-4-[3-amino-1-(trifluoromethyl)propoxy]-1H-pyrazolo[3,4-b]pyridine-5-carboxylic Acid Ethyl Ester; CAS 860610-42-0; Pyrazolopyridine intermediate 860610-42-0; Trifluoromethyl pyrazolopyridine derivative
EINECS	Contact for details

Quality Control

Our Ethyl 4-[3-Amino-1-(Trifluoromethyl)Propoxy]-1-Methyl-1H-Pyrazolo[3,4-B]Pyridine-5-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure compliance with stringent specifications for pharmaceutical intermediates. Certificates of Analysis (COA) detailing batch-specific results are provided and can be tailored to meet specific client or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.