Description

6-Chloro-5-Fluoro-Pyridine-2-Carboxylic Acid is a high-purity, multi-functional heterocyclic building block essential for advanced organic synthesis. Its unique halogenated pyridine structure makes it a critical intermediate for developing novel active pharmaceutical ingredients (APIs) and agrochemicals. This compound is primarily sought by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, particularly in kinase inhibitor and antiviral research.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides due to its bioactive pyridine core.
• Ligand & Catalyst Preparation: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of functionalized polymers and advanced organic electronic materials.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects and scale-up process development.
• Academic & Industrial R&D: Used in medicinal chemistry and chemical biology research for structure-activity relationship (SAR) studies.

Basic Information

Product Name	6-Chloro-5-Fluoro-Pyridine-2-Carboxylic Acid
CAS No.	860296-24-8
Molecular Formula	C6H3ClFNO2
Molecular Weight	175.54 g/mol
Synonyms	2-Pyridinecarboxylic acid, 6-chloro-5-fluoro-; 6-Chloro-5-fluoropicolinic acid; 5-Fluoro-6-chloropyridine-2-carboxylic acid; 6-Chloro-5-fluoro-2-pyridinecarboxylic acid; 6-Chloro-5-fluoropyridine-2-carboxylic acid; 2-Carboxy-6-chloro-5-fluoropyridine; 6-Chloro-5-fluoro-2-picolinic acid
EINECS	Contact for details

Quality Control

Our 6-Chloro-5-Fluoro-Pyridine-2-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports applications requiring high standards, including cGMP development and commercial-scale production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids, bases, and oxidizing agents. Due to its nature as a strong acid/organic solvent, handle with appropriate personal protective equipment in a fume hood or well-ventilated area.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.