Description

n-Boc-Thiomorpholine-3-Carboxylic Acid Ethyl Ester is a high-purity, protected heterocyclic building block essential for advanced organic synthesis. This compound matters as a key chiral intermediate, enabling the efficient construction of complex molecular architectures with high stereochemical fidelity. Pharmaceutical researchers and fine chemical manufacturers need it for the development of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting neurological and oncological diseases.

Application

• Pharmaceutical Intermediate: A critical chiral synthon in the multi-step synthesis of complex drug candidates and novel bioactive molecules.
• Peptidomimetic Research: Used to incorporate constrained thiomorpholine scaffolds into peptide backbones to enhance metabolic stability and bioavailability.
• Ligand and Catalyst Development: Serves as a precursor for creating novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme function and protein-protein interactions.
• Custom Synthesis & Contract Manufacturing: A fundamental building block supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.
• Academic & Industrial R&D: Supports discovery chemistry in both academic institutions and industrial R&D laboratories focused on heterocyclic chemistry.

Basic Information

Product Name	n-Boc-Thiomorpholine-3-Carboxylic Acid Ethyl Ester
CAS No.	859833-24-2
Molecular Formula	C12H21NO4S
Molecular Weight	275.36 g/mol
Synonyms	Ethyl 1-Boc-3-thiomorpholinecarboxylate; 1-(tert-Butoxycarbonyl)thiomorpholine-3-carboxylic Acid Ethyl Ester; tert-Butyl 3-(ethoxycarbonyl)thiomorpholine-1-carboxylate; Thiomorpholine-3-carboxylic acid, 1-(1,1-dimethylethyl) ester, ethyl ester; Boc-Thiomorpholine-3-COOEt; 1-Boc-3-carbethoxythiomorpholine; Ethyl 1-N-Boc-thiomorpholine-3-carboxylate; 859833-24-2
EINECS	Contact for details

Quality Control

Our n-Boc-Thiomorpholine-3-Carboxylic Acid Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and chiral purity analysis, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) with full traceability are available for every shipment, confirming compliance with specified purity and identity criteria.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed under an inert atmosphere to maximize long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.