Description

6-(Difluoromethoxy)Pyridin-3-Ol CAS NO 859539-04-1 is a high-value fluorinated pyridine derivative, a key building block in modern synthetic chemistry. Its unique structure, featuring a difluoromethoxy substituent, is critical for modulating the physicochemical and metabolic properties of target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, where it is used to create novel active ingredients with enhanced efficacy and stability.

Application

• Pharmaceutical Intermediate: A crucial synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitors and central nervous system (CNS) targeted drugs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the difluoromethoxy group can improve lipophilicity and biological activity.
• Material Science Precursor: Serves as a building block for specialty chemicals, including liquid crystals and organic electronic materials.
• Chemical Research & Development: Employed in academic and industrial R&D labs for exploring new fluorination methodologies and constructing complex heterocyclic scaffolds.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis projects requiring the introduction of a difluoromethoxypyridine moiety.

Basic Information

Product Name	6-(Difluoromethoxy)Pyridin-3-Ol
CAS No.	859539-04-1
Molecular Formula	C6H5F2NO2
Molecular Weight	161.11 g/mol
Synonyms	3-Hydroxy-6-(difluoromethoxy)pyridine; 6-(Difluoromethoxy)-3-pyridinol; 6-(Difluoromethoxy)-3-hydroxypyridine; 3-Pyridinol, 6-(difluoromethoxy)-; 6-Difluoromethoxypyridin-3-ol; 859539-04-1; 6-(Difluoromethoxy)-3-pyridinone (tautomer)
EINECS	Contact for details

Quality Control

Our 6-(Difluoromethoxy)Pyridin-3-Ol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and batch-to-batch consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This material is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere if possible.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.