Description

5-(Difluoromethyl)Picolinic Acid is a high-purity, specialized heterocyclic building block featuring a difluoromethyl group at the 5-position of the picolinic acid scaffold. This compound is valued for its role in modulating the physicochemical and metabolic properties of target molecules, making it a critical intermediate in advanced research and development. It is primarily sought after by pharmaceutical and agrochemical R&D teams for the synthesis of novel active ingredients, where its unique fluorine substitution pattern is leveraged to enhance potency and stability.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting enzyme inhibition.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides, where the difluoromethyl group can improve biological activity and environmental profile.
• Ligand Synthesis: Serves as a precursor for creating complex ligands in catalysis and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying biological pathways and target engagement.
• Fine Chemical Synthesis: A versatile building block for constructing complex, fluorinated organic molecules in custom synthesis projects.

Basic Information

Product Name	5-(Difluoromethyl)Picolinic Acid
CAS No.	859538-41-3
Molecular Formula	C7H5F2NO2
Molecular Weight	173.12 g/mol
Synonyms	5-(Difluoromethyl)pyridine-2-carboxylic acid; 2-Pyridinecarboxylic acid, 5-(difluoromethyl)-; 5-Difluoromethylpicolinic acid; 5-(Difluoromethyl)-2-pyridinecarboxylic acid; Picolinic acid, 5-(difluoromethyl)-
EINECS	Contact for details

Quality Control

Our 5-(Difluoromethyl)Picolinic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.