Description

T-Boc-n-Amido-Peg4-Nhs Ester is a heterobifunctional polyethylene glycol (PEG) crosslinker featuring a tert-butyloxycarbonyl (BOC) protected amine at one terminus and an amine-reactive N-hydroxysuccinimide (NHS) ester at the other. This compound is critical for creating stable, cleavable linkages in bioconjugation and drug delivery systems, offering controlled release profiles. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostics industries for the development of antibody-drug conjugates (ADCs), peptide synthesis, and advanced polymer therapeutics.

Application

• Antibody-Drug Conjugate (ADC) Linker: Serves as a key building block for constructing cleavable, PEGylated linkers that connect cytotoxic payloads to monoclonal antibodies, enhancing solubility and pharmacokinetics.
• Peptide and Protein Modification: Used to introduce BOC-protected amine handles or PEG spacers onto peptides, proteins, and other biomolecules via the reactive NHS ester group.
• Polymer Therapeutics and Drug Delivery: Enables the synthesis of sophisticated, stimuli-responsive drug delivery vehicles where the BOC group allows for triggered release of the active agent.
• Biomaterial Functionalization: Facilitates the surface modification of nanoparticles, hydrogels, and medical devices with bioactive ligands to improve biocompatibility and targeting.
• Proteomics Research: Acts as a crosslinking reagent for studying protein-protein interactions or for the stable immobilization of proteins on solid supports.
• Diagnostic Reagent Synthesis: Employed in the development of contrast agents, fluorescent probes, and other diagnostic tools requiring specific, stable conjugation chemistry.

Basic Information

Product Name	T-Boc-n-Amido-Peg4-Nhs Ester
CAS No.	859230-20-9
Molecular Formula	C24H42N2O11
Molecular Weight	534.60 g/mol
Synonyms	1-Boc-2,5,8,11-tetraoxatetradecan-14-amine, 13-oxo-, 2,5-dioxopyrrolidin-1-yl ester; tert-Butyl (17-oxo-4,7,10,13-tetraoxa-16-azaheptadecan-1-yl)carbamate, NHS ester; BOC-NH-PEG4-NHS; Boc-N-amido-PEG4-NHS ester; 2,5-Dioxopyrrolidin-1-yl 1-[(1,1-dimethylethoxy)carbonyl]amino-3,6,9,12-tetraoxapentadecan-15-oate; BOC-Amine-PEG4-NHS; N-(t-Boc)-3,6,9,12-tetraoxapentadecan-15-amide, N-hydroxysuccinimide ester
EINECS	Contact for details

Quality Control

Our T-Boc-n-Amido-Peg4-Nhs Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity assessment and NMR for structural confirmation, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This material is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a dry environment before opening to minimize condensation and hydrolysis of the active ester.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMF, DMSO, acetonitrile, dichloromethane

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.