Description

(R)-tert-Butyl (1-(5-Bromo-3-Fluoropyridin-2-Yl)Ethyl)Carbamate is a high-purity chiral intermediate of significant importance in modern pharmaceutical synthesis. This compound matters because it provides a critical, enantiomerically pure building block for the development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring high specificity. Pharmaceutical R&D teams and fine chemical manufacturers need this material for constructing complex molecules where the stereochemical configuration is essential for biological activity and drug efficacy.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of new drug candidates, especially in kinase inhibitor programs.
• Active Pharmaceutical Ingredient (API) Synthesis: Used in the multi-step synthesis of complex target molecules where the (R)-configuration is required for therapeutic effect.
• Agrochemical Research: Potential application as a building block for developing advanced, enantiomerically pure agrochemicals and pesticides.
• Ligand and Catalyst Development: Can be utilized in the preparation of chiral ligands or organocatalysts for asymmetric synthesis.
• Chemical Biology Probes: Employed in the creation of molecular probes for studying biological pathways and target engagement.
• Custom Synthesis and Contract Manufacturing: A critical starting material for CDMOs (Contract Development and Manufacturing Organizations) specializing in complex, chiral molecules.

Basic Information

Product Name	(R)-tert-Butyl (1-(5-Bromo-3-Fluoropyridin-2-Yl)Ethyl)Carbamate
CAS No.	858414-25-2
Molecular Formula	C12H16BrFN2O2
Molecular Weight	319.17 g/mol
Synonyms	Carbamic acid, N-[(1R)-1-(5-bromo-3-fluoro-2-pyridinyl)ethyl]-, 1,1-dimethylethyl ester; tert-Butyl (R)-(1-(5-bromo-3-fluoropyridin-2-yl)ethyl)carbamate; (R)-1-(5-Bromo-3-fluoropyridin-2-yl)ethyl carbamic acid tert-butyl ester; Boc-(R)-Amino(5-bromo-3-fluoropyridin-2-yl)ethane; (R)-Boc-5-Bromo-3-fluoro-2-pyridineethylamine; (R)-N-Boc-1-(5-Bromo-3-fluoropyridin-2-yl)ethylamine; (R)-tert-Butyl 1-(5-bromo-3-fluoropyridin-2-yl)ethylcarbamate
EINECS	Contact for details

Quality Control

Our (R)-tert-Butyl (1-(5-Bromo-3-Fluoropyridin-2-Yl)Ethyl)Carbamate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high enantiomeric purity. The product undergoes rigorous analytical testing, including chiral HPLC, to confirm identity, purity, and the absence of critical impurities. Certificates of Analysis (COA) detailing specific results for each batch are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if necessary to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual unknown impurity ≤ 0.5%, Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.