Description

tert-Butyl 5-Fluorospiro[Indoline-3,4'-Piperidine]-1-Carboxylate is a high-value, advanced pharmaceutical intermediate featuring a unique spirocyclic scaffold. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel bioactive molecules targeting central nervous system (CNS) disorders. It is primarily sought after by pharmaceutical R&D teams, contract research organizations (CROs), and fine chemical manufacturers engaged in the development of new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potential drug candidates, especially those with spirocyclic architectures.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for novel targets.
• CNS Drug Discovery: Serves as a core scaffold for developing compounds targeting neurological and psychiatric conditions.
• Proteolysis Targeting Chimera (PROTAC) Development: Can be utilized as a linker or component in the design of bifunctional degraders.
• Chemical Biology Probes: Employed in the creation of tool compounds for studying biological pathways and protein function.
• Custom Synthesis: A starting material for the contract manufacturing of specialized, non-commercial compounds for clinical trials.

Basic Information

Product Name	tert-Butyl 5-Fluorospiro[Indoline-3,4'-Piperidine]-1-Carboxylate
CAS No.	858351-47-0
Molecular Formula	C17H23FN2O2
Molecular Weight	306.38 g/mol
Synonyms	1-Boc-5-Fluoro-spiro[indoline-3,4'-piperidine]; 5-Fluoro-1-[(2-methyl-2-propanyl)oxycarbonyl]spiro[indole-3,4'-piperidine]; tert-Butyl 5-fluoro-1,3-dihydrospiro[indene-2,4'-piperidine]-1-carboxylate (related); 5-Fluoro-1-N-Boc-spiro[indoline-3,4'-piperidine]; Spiro[indoline-3,4'-piperidine]-1-carboxylic acid, 5-fluoro-, 1,1-dimethylethyl ester; 858351-47-0; 1,1-Dimethylethyl 5-fluoro-2,3-dihydro-1'H-spiro[indole-3,4'-piperidine]-1-carboxylate
EINECS	Contact for details

Quality Control

Our tert-Butyl 5-Fluorospiro[Indoline-3,4'-Piperidine]-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting compliance with cGMP standards for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed in a desiccated environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.