Description

1H-Pyrrolo[2,3-B]Pyridine-3-Carboxylic Acid, 5-Nitro-1-(Phenylsulfonyl)-, Methyl Ester is a high-purity, advanced pharmaceutical intermediate characterized by its complex heterocyclic structure. This compound is critical for medicinal chemistry research and development, serving as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries for creating targeted therapeutic agents.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of complex drug candidates, particularly those targeting kinase inhibition and other specific biological pathways.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Process Chemistry Development: Serves as a key raw material for scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales.
• Bioconjugation & Probe Synthesis: Can be utilized in the development of chemical probes, diagnostic agents, or antibody-drug conjugates (ADCs) due to its functionalizable core.
• Academic & Contract Research: Employed in university laboratories and contract research organizations (CROs) for exploratory synthetic chemistry and novel methodology development.

Basic Information

Product Name	1H-Pyrrolo[2,3-B]Pyridine-3-Carboxylic Acid, 5-Nitro-1-(Phenylsulfonyl)-, Methyl Ester
CAS No.	858340-91-7
Molecular Formula	C15H11N3O6S
Molecular Weight	361.33 g/mol
Synonyms	Methyl 5-nitro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine-3-carboxylate; 1H-Pyrrolo[2,3-b]pyridine-3-carboxylic acid, 5-nitro-1-(phenylsulfonyl)-, methyl ester; 5-Nitro-1-tosyl-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid methyl ester; 858340-91-7; 1-(Phenylsulfonyl)-5-nitro-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid methyl ester; Methyl 5-nitro-1-tosyl-1H-pyrrolo[2,3-b]pyridine-3-carboxylate
EINECS	Contact for details

Quality Control

Our 1H-Pyrrolo[2,3-B]Pyridine-3-Carboxylic Acid, 5-Nitro-1-(Phenylsulfonyl)-, Methyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications and test results are provided with each shipment. We support development and commercial projects with material produced under current Good Manufacturing Practice (cGMP) guidelines as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep the container tightly sealed in a dry environment to protect the compound from moisture.

Specification

Item	Specification
Appearance	Off-white to yellow crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.