Description

Methanone, (5-Bromo-1H-Pyrrolo[2,3-B]Pyridin-3-Yl)Phenyl- is a high-purity, advanced pharmaceutical intermediate with the CAS number 858117-40-5. This compound is a critical building block in modern medicinal chemistry, valued for its role in constructing complex molecular architectures. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, particularly in oncology and kinase inhibitor research.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of targeted small-molecule drugs, especially kinase inhibitors.
• Oncology Research: Used in the discovery and development of novel anti-cancer compounds due to its privileged pyrrolopyridine scaffold.
• Chemical Biology: Serves as a probe or precursor for labeling studies in proteomics and target identification.
• Process Chemistry: Employed in route scouting and optimization for the scalable production of active pharmaceutical ingredients (APIs).
• Academic Research: Utilized in universities and R&D labs for methodological studies in heterocyclic and organobromine chemistry.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting global drug development pipelines.

Basic Information

Product Name	Methanone, (5-Bromo-1H-Pyrrolo[2,3-B]Pyridin-3-Yl)Phenyl-
CAS No.	858117-40-5
Molecular Formula	C₁₄H₉BrN₂O
Molecular Weight	301.14 g/mol
Synonyms	(5-Bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)(phenyl)methanone; 5-Bromo-3-benzoyl-1H-pyrrolo[2,3-b]pyridine; Phenyl(5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)methanone; 858117-40-5; 5-Bromo-3-benzoylpyrrolo[2,3-b]pyridine; 3-Benzoyl-5-bromo-1H-pyrrolo[2,3-b]pyridine
EINECS	Contact for details

Quality Control

Our Methanone, (5-Bromo-1H-Pyrrolo[2,3-B]Pyridin-3-Yl)Phenyl- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, supporting its use in regulated research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.