Description

1H-Pyrrolo[2,3-B]Pyridine-3-Methanamine, 4-Bromo-N,n-Dimethyl-1-[Tris(1-Methylethyl)Silyl]- is a high-purity, advanced pharmaceutical intermediate featuring a complex heterocyclic core protected by a silyl group. This compound is critical for enabling sophisticated synthetic routes in medicinal chemistry, particularly for the development of kinase inhibitors and other targeted therapeutics. It is primarily utilized by research institutions and pharmaceutical companies engaged in the synthesis of novel active pharmaceutical ingredients (APIs) and drug discovery programs.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of complex drug molecules, especially kinase inhibitors.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for new therapeutic candidates.
• Organic Synthesis: Serves as a versatile precursor for further functionalization via cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) facilitated by the bromo substituent.
• Process Chemistry Development: Employed in scaling up synthetic routes from laboratory to pilot plant scale for clinical trial material production.
• Bioconjugation & Probe Synthesis: The amine functionality allows for conjugation to fluorescent tags or biotin for biological assay development.

Basic Information

Product Name	1H-Pyrrolo[2,3-B]Pyridine-3-Methanamine, 4-Bromo-N,n-Dimethyl-1-[Tris(1-Methylethyl)Silyl]-
CAS No.	858116-79-7
Molecular Formula	C19H32BrN3Si
Molecular Weight	410.47 g/mol
Synonyms	4-Bromo-N,N-dimethyl-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine-3-methanamine; 1-(Triisopropylsilyl)-4-bromo-N,N-dimethyl-1H-pyrrolo[2,3-b]pyridine-3-methanamine; 4-Bromo-1-TIPS-N,N-dimethyl-1H-pyrrolo[2,3-b]pyridine-3-methanamine; TIPS-Protected 4-Bromo-7-azaindole-3-methylamine derivative; 858116-79-7; 4-Bromo-1-(triisopropylsilyl)-N,N-dimethyl-1H-pyrrolo[2,3-b]pyridine-3-methanamine
EINECS	Contact for details

Quality Control

Our 1H-Pyrrolo[2,3-B]Pyridine-3-Methanamine, 4-Bromo-N,n-Dimethyl-1-[Tris(1-Methylethyl)Silyl]- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and mass spectrometry, to ensure compliance with stringent specifications for pharmaceutical R&D use. Certificates of Analysis (COA) detailing all test results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.