Description

5-Bromo-1-Triisopropylsilanyl-1H-Pyrrolo[2,3-B]Pyridine is a high-purity, advanced pharmaceutical intermediate featuring a brominated pyrrolopyridine core protected by a triisopropylsilyl (TIPS) group. This compound matters as a critical building block for medicinal chemists, enabling the synthesis of complex molecules with potential therapeutic applications. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), particularly for oncology and central nervous system (CNS) targets.

Application

• Pharmaceutical Intermediate: Key precursor in the multi-step synthesis of complex drug candidates and novel chemical entities.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for new therapeutic programs.
• Heterocyclic Compound Synthesis: Serves as a versatile scaffold for constructing fused-ring systems common in modern drug discovery.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, or Buchwald-Hartwig amination.
• Chemical Biology Probes: Can be utilized in the development of molecular probes for studying biological pathways and target engagement.
• Agrochemical Research: Potential intermediate for developing new crop protection agents and pesticides.
• Material Science: May be investigated as a component in the synthesis of organic electronic materials or specialty polymers.

Basic Information

Product Name	5-Bromo-1-Triisopropylsilanyl-1H-Pyrrolo[2,3-B]Pyridine
CAS No.	858116-66-2
Molecular Formula	C17H27BrN2Si
Molecular Weight	367.40 g/mol
Synonyms	1H-Pyrrolo[2,3-b]pyridine, 5-bromo-1-[(1,1-dimethylethyl)dimethylsilyl]-; 5-Bromo-1-(tert-butyldimethylsilyl)-1H-pyrrolo[2,3-b]pyridine (common error/alternative); 5-Bromo-1-TIPS-pyrrolo[2,3-b]pyridine; 5-Bromo-1-triisopropylsilyl-1H-pyrrolo[2,3-b]pyridine; TIPS-Protected 5-Bromopyrrolopyridine; 858116-66-2; 5-Bromo-1-((triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine
EINECS	Contact for details

Quality Control

Our 5-Bromo-1-Triisopropylsilanyl-1H-Pyrrolo[2,3-B]Pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with the standards expected for advanced pharmaceutical intermediates in global R&D and cGMP environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Single Unknown Impurity (HPLC)	≤1.0%
Total Impurities (HPLC)	≤3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.