Description

1H-Pyrrolo[2,3-B]Pyridine-3-Methanamine, N,n-Dimethyl-1-[Tris(1-Methylethyl)Silyl]- is a sophisticated, silyl-protected heterocyclic amine building block of significant interest in advanced organic synthesis. Its value lies in its role as a key intermediate for constructing complex molecular architectures, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists working on novel active pharmaceutical ingredients (APIs), especially within therapeutic areas targeting kinase inhibition and other critical biological pathways.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of novel drug candidates, particularly kinase inhibitors and other small molecule therapeutics.
• Medicinal Chemistry Research: Used extensively in lead optimization and structure-activity relationship (SAR) studies to develop new chemical entities with improved potency and selectivity.
• Process Chemistry Development: Employed in scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales for new APIs.
• Chemical Biology Probes: Utilized in the construction of specialized molecular probes for studying enzyme function and cellular signaling pathways.
• Agrochemical Synthesis: Acts as a building block for developing new, high-performance crop protection agents with novel modes of action.
• Material Science Research: Investigated as a monomer or functional component in the development of advanced organic electronic materials and polymers.

Basic Information

Item	Details
Product Name	1H-Pyrrolo[2,3-B]Pyridine-3-Methanamine, N,n-Dimethyl-1-[Tris(1-Methylethyl)Silyl]-
CAS No.	858116-59-3
Molecular Formula	C19H33N3Si
Molecular Weight	331.57 g/mol
Synonyms	N,N-Dimethyl-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine-3-methanamine; 1-(Triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine-3-methanamine, N,N-dimethyl-; 3-(Dimethylaminomethyl)-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine; TIPS-Protected 7-Azaindole Derivative; Silylated Azaindole Building Block; 1-TIPS-3-(dimethylaminomethyl)-7-azaindole; 1-Triisopropylsilyl-3-(dimethylaminomethyl)-1H-pyrrolo[2,3-b]pyridine
EINECS	Contact for details

Quality Control

Our 1H-Pyrrolo[2,3-B]Pyridine-3-Methanamine, N,n-Dimethyl-1-[Tris(1-Methylethyl)Silyl]- is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research and development applications. All batches are characterized by advanced analytical techniques including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. For long-term storage, it is recommended to keep the material under an inert atmosphere (e.g., nitrogen or argon) at temperatures between 2°C and 8°C to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.