Description

1-tert-Butyl 4-Methyl (2S)-2-{[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino}Butanedioate is a high-purity, protected amino acid derivative essential for advanced peptide synthesis. This compound serves as a critical building block, offering precise stereochemical control and protecting group compatibility for constructing complex biomolecules. It is primarily required by pharmaceutical R&D laboratories, biotechnology companies, and fine chemical manufacturers engaged in the development of peptide-based therapeutics, diagnostics, and research reagents.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key Fmoc-protected intermediate for the sequential assembly of peptides on resin.
• Solution-Phase Peptide Synthesis: Used in classical coupling reactions for the synthesis of short peptide sequences or peptide fragments.
• Pharmaceutical Intermediate: Serves as a crucial precursor in the research and development of novel peptide drugs and active pharmaceutical ingredients (APIs).
• Bioconjugation: Employed in the chemical modification of proteins, antibodies, or other biomolecules to attach labels, drugs, or polymers.
• Combinatorial Chemistry: Utilized in libraries for drug discovery to generate diverse arrays of peptide-like compounds for screening.
• Academic & Industrial Research: A fundamental reagent for studying peptide structure-activity relationships (SAR) and developing new synthetic methodologies.

Basic Information

Product Name	1-tert-Butyl 4-Methyl (2S)-2-{[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino}Butanedioate
CAS No.	858034-72-7
Molecular Formula	C24H27NO6
Molecular Weight	425.48 g/mol
Synonyms	Fmoc-Asp(OtBu)-OMe; (2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]butanedioic acid 1-tert-butyl 4-methyl ester; Fmoc-L-aspartic acid 4-tert-butyl 1-methyl ester; Fmoc-Asp(OtBu)-OMe; Fmoc-Aspartyl(OtBu)-OMe; Methyl N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-aspartate 4-tert-butyl ester; N-α-Fmoc-L-aspartic acid β-tert-butyl α-methyl ester; N-Fmoc-L-aspartic acid 4-tert-butyl 1-methyl ester
EINECS	Contact for details

Quality Control

Our production of this peptide building block adheres to stringent quality protocols suitable for research and pharmaceutical applications. Every batch is characterized by advanced analytical techniques including HPLC, NMR, and mass spectrometry to confirm identity, chiral purity, and chemical integrity. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to ensure traceability and compliance with your project specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry environment. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.