Description

4-Amino-5-Bromo-2-Chloropyridine is a high-purity, multi-functional halogenated pyridine derivative serving as a critical building block in advanced organic synthesis. Its unique substitution pattern makes it a versatile intermediate for constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs) and specialty agrochemicals. This compound is essential for research and production chemists in the pharmaceutical, agrochemical, and material science industries seeking to introduce specific halogen and amino functionalities into heterocyclic systems.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides with improved efficacy.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in transition metal catalysis and coordination chemistry.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as charge-transport layers or photoactive compounds.
• Chemical Biology Probes: Useful for constructing molecular probes and tags for studying biological processes and target engagement.
• Custom Synthesis and Contract Manufacturing: A valuable scaffold for custom synthesis services and scale-up production under cGMP conditions.

Basic Information

Product Name	4-Amino-5-Bromo-2-Chloropyridine
CAS No.	857730-21-3
Molecular Formula	C5H4BrClN2
Molecular Weight	207.46 g/mol
Synonyms	5-Bromo-2-chloro-4-pyridinamine; 2-Chloro-5-bromo-4-aminopyridine; 4-Pyridinamine, 5-bromo-2-chloro-; 5-Bromo-2-chloropyridin-4-amine; 4-Amino-5-bromo-2-chloropyridine; 2-Chloro-4-amino-5-bromopyridine; ABACP; 4-AB-2-CP
EINECS	Contact for details

Quality Control

Our 4-Amino-5-Bromo-2-Chloropyridine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive analytical documentation, including Certificates of Analysis (COA) with detailed results from HPLC, NMR, and mass spectrometry. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, and we support customer audits and regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.