Description

tert-Butyl 6-Chloro-1,2-Dihydrospiro[Piperidine-4,3-Pyrrolo[3,2-B]Pyridine]-1-Carboxylate is a high-purity, advanced pharmaceutical intermediate of significant interest in modern drug discovery. This spirocyclic compound serves as a critical building block for the synthesis of novel, bioactive molecules targeting a range of therapeutic areas. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of new chemical entities, particularly for central nervous system (CNS) and oncology applications.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly those with spirocyclic or fused heterocyclic architectures.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop novel pharmacophores.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a potential linker or warhead component in the design of targeted protein degradation therapeutics.
• Kinase Inhibitor Synthesis: Employed in the construction of selective kinase inhibitors due to its privileged piperidine-pyrrolopyridine scaffold.
• Chemical Biology Probes: Utilized to create tool compounds for investigating biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: Supplied for bespoke synthesis projects requiring high-fidelity, complex intermediates.

Basic Information

Item	Details
Product Name	tert-Butyl 6-Chloro-1,2-Dihydrospiro[Piperidine-4,3-Pyrrolo[3,2-B]Pyridine]-1-Carboxylate
CAS No.	857730-15-5
Molecular Formula	C16H20ClN3O2
Molecular Weight	321.80 g/mol
Synonyms	1-Boc-6-chloro-1,2-dihydrospiro[piperidine-4,3'-pyrrolo[3,2-b]pyridine]; 6-Chloro-1,2-dihydrospiro[piperidine-4,3'-pyrrolo[3,2-b]pyridine]-1-carboxylic acid tert-butyl ester; tert-Butyl 6-chloro-2,3-dihydro-1'H-spiro[piperidine-4,3'-pyrrolo[3,2-b]pyridine]-1'-carboxylate; 857730-15-5; Spiro[piperidine-4,3'-pyrrolo[3,2-b]pyridine]-1'-carboxylic acid, 6-chloro-1,2-dihydro-, 1,1-dimethylethyl ester; 1,1-Dimethylethyl 6-chloro-1,2-dihydrospiro[piperidine-4,3'-pyrrolo[3,2-b]pyridine]-1'-carboxylate
EINECS	Contact for details

Quality Control

Our tert-Butyl 6-Chloro-1,2-Dihydrospiro[Piperidine-4,3-Pyrrolo[3,2-B]Pyridine]-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific project requirements. We adhere to cGMP guidelines for the production of pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider holding under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.