Description

tert-Butyl 2',3'-Dihydrospiro{Piperidine-4,1'-Pyrrolo[2,3-C]Pyridine}-1-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic and fused heterocyclic structure. This compound is of significant value in medicinal chemistry for its role as a key building block in the synthesis of novel drug candidates, particularly those targeting the central nervous system and oncology. It is primarily sought after by research institutions, contract research and manufacturing organizations (CRMOs/CROs), and pharmaceutical companies engaged in the development of new chemical entities.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of potential therapeutic agents, especially kinase inhibitors and neuroactive compounds.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Process Development & Scale-up: Employed in the development and optimization of robust, scalable synthetic routes for active pharmaceutical ingredients (APIs).
• Academic Research: Utilized in university and institutional labs for studying novel organic reactions and heterocyclic chemistry.
• Custom Synthesis: A starting material for the contract manufacturing of specialized, non-commercial compounds for client-specific research needs.

Basic Information

Product Name	tert-Butyl 2',3'-Dihydrospiro{Piperidine-4,1'-Pyrrolo[2,3-C]Pyridine}-1-Carboxylate
CAS No.	857730-11-1
Molecular Formula	C16H21N3O2
Molecular Weight	287.36 g/mol
Synonyms	1-Boc-2',3'-dihydrospiro[piperidine-4,1'-pyrrolo[2,3-c]pyridine]; tert-Butyl 2,3-dihydrospiro[piperidine-4,1'-pyrrolo[2,3-c]pyridine]-1-carboxylate; 1-(tert-Butoxycarbonyl)-2',3'-dihydrospiro[piperidine-4,1'-pyrrolo[2,3-c]pyridine]; Spiro[piperidine-4,1'-pyrrolo[2,3-c]pyridine]-1-carboxylic acid, 2',3'-dihydro-, 1,1-dimethylethyl ester; 857730-11-1; 1-Boc-2,3-dihydrospiro[piperidine-4,1'-pyrrolo[2,3-c]pyridine]
EINECS	Contact for details

Quality Control

Our tert-Butyl 2',3'-Dihydrospiro{Piperidine-4,1'-Pyrrolo[2,3-C]Pyridine}-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring the material meets the stringent requirements for pharmaceutical R&D and pre-clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when prolonged exposure is anticipated to prevent degradation. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.