Description

2-Bromo-3-difluoromethoxy-6-iodopyridine is a highly functionalized pyridine derivative, serving as a critical multi-halogenated building block in advanced organic synthesis. Its unique structure, featuring bromine, iodine, and a difluoromethoxy group, makes it exceptionally valuable for constructing complex molecules through sequential cross-coupling reactions. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Research: Used in the discovery and development of new herbicides, fungicides, and insecticides, leveraging the bioactivity of halogenated heterocycles.
• Material Science: Serves as a monomer or functionalization agent in the creation of specialty polymers and liquid crystals, where the fluorine atoms can impart desirable properties.
• Cross-Coupling Reactions: An ideal substrate for Suzuki, Stille, and Negishi couplings, allowing for selective functionalization at the iodine or bromine sites to create diverse chemical libraries.
• Chemical Biology: Employed as a molecular probe or tag in medicinal chemistry programs due to its distinct halogen handles for bioconjugation.

Basic Information

Product Name	2-Bromo-3-difluoromethoxy-6-iodopyridine
CAS No.	857295-23-9
Molecular Formula	C6H3BrF2INO
Molecular Weight	375.90 g/mol
Synonyms	6-Iodo-2-bromo-3-(difluoromethoxy)pyridine; 3-(Difluoromethoxy)-2-bromo-6-iodopyridine; 2-Bromo-6-iodo-3-(difluoromethoxy)pyridine; Pyridine, 2-bromo-3-(difluoromethoxy)-6-iodo-; 857295-23-9; 2-Br-3-(OCHF2)-6-I-Pyridine
EINECS	Contact for details

Quality Control

Every batch of 2-Bromo-3-difluoromethoxy-6-iodopyridine is manufactured under strict quality management systems. We provide comprehensive analytical data to ensure identity, purity, and consistency for your critical research and development processes. A detailed Certificate of Analysis (COA) is supplied with each shipment, typically including results from HPLC, NMR, and mass spectrometry.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container sealed to minimize exposure to moisture and atmospheric oxygen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.