Description

(E)-n-Benzyl-3-(6-Bromopyridin-2-Yl)-2-Cyanoacrylamide is a high-purity, advanced pharmaceutical intermediate characterized by its specific stereochemistry and functional groups. This compound is valued for its role as a critical building block in the synthesis of complex bioactive molecules, particularly in medicinal chemistry. It is primarily sought by research institutions and pharmaceutical companies engaged in the development of new therapeutic agents, including kinase inhibitors and other targeted small-molecule drugs.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of novel drug candidates, especially in oncology and neurology research.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes due to its versatile pyridine and acrylamide scaffold.
• Chemical Biology Probes: Serves as a core structure for developing molecular probes to study enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds under cGMP conditions.
• Academic Research: Utilized in university and institutional labs for fundamental research in organic synthesis and heterocyclic chemistry.

Basic Information

Product Name	(E)-n-Benzyl-3-(6-Bromopyridin-2-Yl)-2-Cyanoacrylamide
CAS No.	857064-40-5
Molecular Formula	C16H12BrN3O
Molecular Weight	342.19 g/mol
Synonyms	(E)-N-Benzyl-3-(6-bromopyridin-2-yl)-2-cyanoacrylamide; 2-Propenamide, N-benzyl-3-(6-bromo-2-pyridinyl)-2-cyano-, (2E)-; (E)-N-Benzyl-3-(6-bromo-2-pyridyl)-2-cyanoacrylamide; (2E)-N-Benzyl-3-(6-bromopyridin-2-yl)-2-cyanoacrylamide; 857064-40-5; (E)-N-Benzyl-3-(6-bromo-2-pyridinyl)-2-cyano-2-propenamide
EINECS	Contact for details

Quality Control

Our (E)-n-Benzyl-3-(6-Bromopyridin-2-Yl)-2-Cyanoacrylamide is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality system is designed to meet the stringent requirements of pharmaceutical R&D, and we can support projects requiring compliance with cGMP guidelines for non-clinical use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.5%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.