Description

4,5-Dichloro-2-Hydroxypyridine is a halogenated pyridine derivative that serves as a versatile and critical building block in advanced organic synthesis. Its unique structure, featuring both hydroxyl and chloro substituents, makes it a valuable precursor for constructing complex heterocyclic systems and active pharmaceutical ingredients (APIs). This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for developing new molecules with targeted biological activity.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel drug candidates, particularly in antiviral, antibacterial, and central nervous system (CNS) active compounds.
• Agrochemical Synthesis: Used as a core structure for developing new herbicides, fungicides, and insecticides with improved efficacy and selectivity.
• Ligand and Catalyst Preparation: Serves as a precursor for creating specialized ligands used in metal-catalyzed cross-coupling reactions and other catalytic processes.
• Material Science Research: Employed in the development of organic electronic materials, such as charge-transport layers or organic light-emitting diodes (OLEDs).
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis and Contract Manufacturing: A fundamental starting material for custom synthesis projects and scale-up production under cGMP conditions for clinical trial materials.

Basic Information

Product Name	4,5-Dichloro-2-Hydroxypyridine
CAS No.	856965-66-7
Molecular Formula	C5H3Cl2NO
Molecular Weight	163.99 g/mol
Synonyms	2-Hydroxy-4,5-dichloropyridine; 4,5-Dichloro-2-pyridinol; 4,5-Dichloro-2(1H)-pyridinone; 4,5-Dichloro-1H-pyridin-2-one; 4,5-Dichloro-2-hydroxypyridine; 2-Pyridinol, 4,5-dichloro-; 4,5-Dichloro-2-pyridone
EINECS	Contact for details

Quality Control

Our 4,5-Dichloro-2-Hydroxypyridine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with your internal specifications and regulatory requirements for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong oxidizing agents and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.