Description

1-Boc-4-[(3-Bromopyridin-4-Yl)Hydroxymethyl]Piperidine is a high-value, multi-functional chemical building block featuring a protected piperidine core with a bromopyridine substituent. This compound is essential for medicinal chemistry research and pharmaceutical development, serving as a key intermediate in the synthesis of complex bioactive molecules. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors to construct novel compounds for screening and optimization.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of potential drug candidates, particularly for central nervous system (CNS) targets and kinase inhibitors.
• Medicinal Chemistry Research: Used in scaffold hopping and structure-activity relationship (SAR) studies to explore new chemical space and optimize lead compounds.
• Agrochemical Synthesis: Serves as a building block for developing novel active ingredients with specific biological activity.
• Ligand and Catalyst Development: The bromopyridine moiety can be utilized in metal-catalyzed cross-coupling reactions to create complex ligands.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying biological pathways and target engagement.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs for the production of bespoke intermediates under cGMP or research-grade conditions.

Basic Information

Product Name	1-Boc-4-[(3-Bromopyridin-4-Yl)Hydroxymethyl]Piperidine
CAS No.	856932-61-1
Molecular Formula	C16H23BrN2O3
Molecular Weight	371.27 g/mol
Synonyms	1-Boc-4-[(3-Bromo-4-pyridinyl)hydroxymethyl]piperidine; tert-Butyl 4-[(3-bromopyridin-4-yl)(hydroxy)methyl]piperidine-1-carboxylate; 4-[(3-Bromopyridin-4-yl)hydroxymethyl]piperidine-1-carboxylic acid tert-butyl ester; 1-(tert-Butoxycarbonyl)-4-[(3-bromopyridin-4-yl)hydroxymethyl]piperidine; 1-Boc-4-(3-bromo-4-pyridylhydroxymethyl)piperidine; Piperidine, 1-[(1,1-dimethylethoxy)carbonyl]-4-[(3-bromo-4-pyridinyl)hydroxymethyl]-; CAS 856932-61-1
EINECS	Contact for details

Quality Control

Our 1-Boc-4-[(3-Bromopyridin-4-Yl)Hydroxymethyl]Piperidine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. For advanced applications, we offer material produced under research-grade or development-grade protocols to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.