Description

4-Bromo-2-Picoline Hcl is a high-purity halogenated pyridine derivative, a crucial building block in advanced organic synthesis. Its value lies in providing a reactive bromine substituent adjacent to the nitrogen atom, enabling selective cross-coupling and functionalization reactions. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, serving as a key intermediate in the development of active ingredients and novel chemical entities. Its reliable quality and consistent performance make it a trusted reagent for process development and scale-up.

Application

• Pharmaceutical Intermediate: A key synthon for the construction of complex drug molecules, particularly in kinase inhibitor and antiviral agent research.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, leveraging its halogenated pyridine core.
• Ligand Precursor: Serves as a starting material for the synthesis of specialized nitrogen-containing ligands used in catalysis.
• Material Science Research: Employed in the development of organic electronic materials and functional polymers.
• Cross-Coupling Reactions: Acts as a pivotal substrate in Suzuki, Stille, and Negishi coupling reactions to form biaryl structures.
• Chemical Reference Standard: Utilized as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Item	Detail
Product Name	4-Bromo-2-Picoline Hcl
CAS No.	856834-97-4
Molecular Formula	C6H7BrClN
Molecular Weight	208.48 g/mol
Synonyms	4-Bromo-2-methylpyridine hydrochloride; 2-Methyl-4-bromopyridine hydrochloride; 4-Bromo-2-picoline hydrochloride; 4-Bromo-2-picolinium chloride; 2-Picoline, 4-bromo-, hydrochloride; 4-Bromo-2-methylpyridinium chloride
EINECS	Contact for details

Quality Control

Every batch of 4-Bromo-2-Picoline Hcl is manufactured under a strict quality management system and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) for all shipments, which include data from HPLC, NMR, and other relevant spectroscopic methods. Our quality commitment aligns with cGMP principles where applicable, supporting our customers' regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.