Description

4-Chloro-2-Methyl-5-Nitropyridine is a high-purity, multi-functional heterocyclic building block of significant importance in advanced organic synthesis. This compound is valued for its reactive halogen and nitro substituents, which enable precise molecular construction in complex chemical processes. It is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the development of active ingredients and novel materials.

Application

This versatile chemical intermediate serves as a key precursor in several high-value industrial and research applications:

• Pharmaceutical Intermediate: A critical building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides, herbicides, and fungicides, leveraging its pyridine core for biological activity.
• Material Science Research: Employed in the development of functional materials, including liquid crystals, organic semiconductors, and metal-organic frameworks (MOFs).
• Cross-Coupling Reactions: Serves as a substrate in palladium-catalyzed reactions (e.g., Suzuki, Buchwald-Hartwig) for creating complex biaryl structures.
• Nucleophilic Aromatic Substitution: The chloro and nitro groups make it an excellent candidate for displacement reactions to introduce diverse functional groups.
• Chemical Research & Development: A valuable tool for medicinal chemists and process chemists in lead optimization and route scouting for new chemical entities.

Basic Information

Product Name	4-Chloro-2-Methyl-5-Nitropyridine
CAS No.	856834-65-6
Molecular Formula	C6H5ClN2O2
Molecular Weight	172.57 g/mol
Synonyms	5-Nitro-4-chloro-2-picoline; 2-Methyl-4-chloro-5-nitropyridine; 4-Chloro-2-methyl-5-nitropyridine; 2-Picoline, 4-chloro-5-nitro-; 5-Nitro-4-chloro-2-methylpyridine; 4-Chloro-5-nitro-2-methylpyridine; 2-Methyl-5-nitro-4-chloropyridine; 4-Chloro-2-picoline, 5-nitro-
EINECS	Contact for details

Quality Control

Our 4-Chloro-2-Methyl-5-Nitropyridine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements of research and industrial-scale synthesis. Comprehensive Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided to guarantee traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	Off-white to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.