Description

4-Chloro-3-Methyl-5-Nitro-Pyridine is a high-purity, multi-functional heterocyclic building block of significant importance in advanced organic synthesis. Its unique substitution pattern makes it a versatile intermediate for constructing complex molecular architectures, particularly in the pharmaceutical and agrochemical sectors. This compound is essential for researchers and process chemists developing active pharmaceutical ingredients (APIs), crop protection agents, and specialty materials where precise halogen and nitro group reactivity is required.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly for kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, leveraging its reactive sites for further functionalization.
• Material Science Research: Serves as a building block for creating functionalized pyridine-based ligands, polymers, and liquid crystals.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and tags for studying biological systems.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to create biaryl systems.
• Nucleophilic Substitution: The chloro and nitro groups provide handles for selective displacement with various nucleophiles to generate diverse chemical libraries.

Basic Information

Product Name	4-Chloro-3-Methyl-5-Nitro-Pyridine
CAS No.	856834-51-0
Molecular Formula	C6H5ClN2O2
Molecular Weight	172.57 g/mol
Synonyms	4-Chloro-3-methyl-5-nitropyridine; 5-Nitro-4-chloro-3-methylpyridine; 3-Methyl-5-nitro-4-chloropyridine; 4-Chloro-3-methyl-5-nitro-pyridine; Pyridine, 4-chloro-3-methyl-5-nitro-; 856834-51-0
EINECS	Contact for details

Quality Control

Our 4-Chloro-3-Methyl-5-Nitro-Pyridine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment ensures the material meets the stringent requirements for research and cGMP-grade pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	Light yellow to yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.