Description

(R)-2,2',3,3'-Tetrahydro-1,1'-Spirobi[1H-Indene]-7,7'-Dicarboxylic Acid is a high-purity, chiral dicarboxylic acid building block of significant interest in advanced organic synthesis. This compound matters for its rigid, spirocyclic structure which provides a unique three-dimensional framework for constructing complex molecules with precise stereochemistry. Pharmaceutical researchers and fine chemical manufacturers need it for developing novel active pharmaceutical ingredients (APIs), chiral catalysts, and sophisticated ligands.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of novel drug candidates, particularly for central nervous system (CNS) and cardiovascular targets.
• Chiral Ligand & Catalyst Synthesis: Serves as a precursor for creating highly selective ligands and organocatalysts used in asymmetric synthesis.
• Advanced Material Science: Used in the research and development of chiral polymers, liquid crystals, and organic frameworks with specific optical properties.
• Agrochemical Research: Employed in the design of new, stereospecific herbicides, fungicides, and plant growth regulators.
• Academic & R&D: A valuable reagent for methodological studies in organic chemistry and stereochemistry at universities and corporate R&D centers.

Basic Information

Product Name	(R)-2,2',3,3'-Tetrahydro-1,1'-Spirobi[1H-Indene]-7,7'-Dicarboxylic Acid
CAS No.	856407-39-1
Molecular Formula	C20H18O4
Molecular Weight	322.36 g/mol
Synonyms	(R)-Spirobiindane-7,7'-dicarboxylic Acid; (7R,7'R)-7,7'-Dihydroxy-7,7'-bi-1H-indene-2,2'(3H,3'H)-dione; (R)-H8-BINOL-7,7'-dicarboxylic Acid; (R)-Tetrahydrospirobiindane-7,7'-dicarboxylic Acid; (R)-2,2',3,3'-Tetrahydro-1,1'-spirobi[indene]-7,7'-dicarboxylic Acid; (R)-Spiro[1H-indene-7,7'-indene]-2,2',3,3'-tetrahydro-1,1'-dicarboxylic Acid; (R)-H8-BINOL-Dicarboxylic Acid
EINECS	Contact for details

Quality Control

Our (R)-2,2',3,3'-Tetrahydro-1,1'-Spirobi[1H-Indene]-7,7'-Dicarboxylic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric excess (ee) and standard purity assays, to ensure compliance with exacting R&D and pharmaceutical intermediate standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound may be moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.